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TEL. 052-798-0180（代表）

〒463-8521 名古屋市守山区大森二丁目１７２３番地

研究業績research achievement


最近の学会発表　presentation

  • 夏目真友子、久次米永子、杉江祥子、林一彦「高歪み小員環化合物 1-azabicyclo[3.1.0]hexane と求電子試薬との反応」第58回日本薬学会東海支部大会2012年7月

  • 小木曽真由美、林一彦 「カルボキシル基を有する常用医薬品に関する調査研究」第57回日本薬学会東海支部大会2011年7月

  • 新保沙織、林一彦 「エステル基を有する常用医薬品に関する調査研究」第57回日本薬学会東海支部大会2017年7月

  • 広兼綾乃、久次米永子、片山肇、林一彦 「1-Azabicyclo[1.1.0]butaneを活用したカルバペネム系経口抗菌剤Tebipenem pivoxilの合成」第57回日本薬学会東海支部大会2011年7月

  • 広兼綾乃、久次米永子、片山肇、林一彦 「1-Azabicyclo[1.1.0]butaneを活用したカルバペネム系経口抗菌剤Tebipenem pivoxilの合成」日本薬学会第131年会2011年 3月

  • 久次米永子、片山肇、林一彦 「高歪み小員環化合物1-azabicyclo[3.1.0]hexaneと求電子試薬との反応」日本薬学会 第130年会2010年 3月

  • 久次米永子、片山肇、林一彦 「高歪み小員環化合物1-azabicyclo[1.1.0]hexaneの合成」日本薬学会 第129年会2009年 3月

  • 久次米永子、片山肇、林一彦 「高歪み小員環の合成研究」日本薬学会 第128年会2008年 3月

  • 久次米永子、片山肇、林一彦 「1-Azabicyclo[1.1.0]butane (ABB)とアシルチアゾリジンとの反応」日本薬学会 第127年会2007年 3月

  • 林一彦、小川志穂、城始勇、佐野茂樹、長尾善光 「ラベプラゾール誘導体における分子内S…N非結合性相互作用」日本薬学会 第126年会2006年 3月

  • 池江克文、橋本佳奈、中島正晃、林一彦、佐野茂樹、長尾善光 「アザビシクロブタンを活用したニューキノロン系抗菌剤の合成」日本薬学会 第126年会2006年 3月

  • 林一彦 「1-Azabicyclo[1.1.0]butaneの合成と応用」日本薬学会東海支部特別講演2006年 1月

  • 長尾善光、林一彦、小川志穂、佐野茂樹　「含イオウ常用医薬品に関する情報収集」日本薬学会 第125年会2005年 3月


論文　paper

  • Hayashi, Kazuhiko　【review】 Synthesis of a strain molecule, 1-Azabicyclo [1.1.0] butane Yakugaku Zasshi (2010), 130(10), 1339-1346.

  • Hayashi, Kazuhiko; Kujime, Eiko; Katayama, Hajime; Sano, Shigeki; Shiro, Motoo; Nagao, Yoshimitsu  Synthesis and reaction of 1-azabicyclo[3.1.0]hexane Chemical & Pharmaceutical Bulletin (2009), 57(10), 1142-1146.

  • Hayashi, Kazuhiko; Kujime, Eiko; Katayama, Hajime; Sano, Shigeki; Nagao, Yoshimitsu   Reaction of 1-azabicyclo[1.1.0]butane with activated amides Heterocycles (2009), 78(7), 1777-1786.

  • Hayashi, Kazuhiko; Ogawa, Shiho; Sano, Shigeki; Shiro, Motoo; Yamaguchi, Kentaro; Sei,　Yoshihisa; Nagao, Yoshimitsu   Intramolecular nonbonded S···N interaction in rabeprazole Chemical & Pharmaceutical Bulletin (2008), 56(6), 802-806. 

  • Ikee, Yoshifumi; Hashimoto, Kana; Kamino, Mai; Nakashima, Masaaki; Hayashi, Kazuhiko; Sano, Shigeki; Shiro, Motoo; Nagao, Yoshimitsu   Synthesis of new quinolone antibiotics utilizing azetidine derivatives obtained from 1-azabicyclo[1.1.0]butane Chemical & Pharmaceutical Bulletin (2008), 56(3), 346-356.

  • Hayashi, Kazuhiko; Kujime, Eiko; Katayama, Hajime; Sano, Shigeki; Nagao, Yoshimitsu   Effects of magnesium salts and amines on the stereoselectivity in the imine aldol reaction Chemical & Pharmaceutical Bulletin (2007), 55(12), 1773-1775.

  • Ikee, Yoshifumi; Hashimoto, Kana; Nakashima, Masaaki; Hayashi, Kazuhiko; Sano, Shigeki; Shiro, Motoo; Nagao, Yoshimitsu  Synthesis and antibacterial activities of new quinolone derivatives utilizing 1-azabicyclo[1.1.0]butane Bioorganic & Medicinal Chemistry Letters (2007), 17(4), 942-945.

  • Nagao Yoshimitsu; Miyamoto Satoshi; Miyamoto Motoyuki; Takeshige Hiroe; Hayashi Kazuhiko; Sano Shigeki; Shiro Motoo; Yamaguchi Kentaro; Sei Yoshihisa  Highly stereoselective asymmetric pummerer reactions that incorporate intermolecular and intramolecular nonbonded S...O interactions.  Journal of the American Chemical Society (2006), 128(30), 9722-9729.

  • Isoda, Takeshi; Hayashi, Kazuhiko; Tamai, Satoshi; Kumagai, Toshio; Nagao, Yoshimitsu Efficient synthesis of isothiocyanates based on the tandem Staudinger/aza-Wittig reactions and mechanistic consideration of the tandem reactions Chemical & Pharmaceutical Bulletin (2006), 54(11), 1616-1619.

  • Abe, Takao; Sato, Chisato; Ushirogochi, Hideki; Sato, Koichi; Takasaki, Tsuyoshi; Isoda, Takeshi; Mihira, Ado; Yamamura, Itsuki; Hayashi, Kazuhiko; Kumagai, Toshio; Tamai, Satoshi; Shiro, Motoo; Venkatesan, Aranapakam M.; Mansour, Tarek S.  A Novel, Mild, and Facile Method To Prepare 6-Methylidene Penem Derivatives.   Journal of Organic Chemistry (2004), 69(18), 5850-5860.

  • Nagao, Yoshimitsu; Tanaka, Satoru; Hayashi, Kazuhiko; Sano, Shigeki; Shiro, Motoo.  New synthetic methods for seven- and eight-membered cyclic ethers based on the ring-expansion reactions of hydroxy or lithioxy methoxyallenylisochroman derivatives.   Synlett (2004), 481-484.

  • Hayashi, Kazuhiko; Ikee, Yoshifumi; Goto, Satoru; Shiro, Motoo; Nagao, Yoshimitsu.  Mechanistic considerations for the consecutive cyclization of 2,3-dibromopropylamine hydrobromide giving a strained molecule, 1-azabicyclo[1.1.0]butane.   Chemical & Pharmaceutical Bulletin (2004), 52(1), 89-94.

  • Nagao Yoshimitsu; Miyamoto Satoshi; Hayashi Kazuhiko; Mihira Ado; Sano Shigeki  Synthesis of new chiral sulfinyldiacetic acid derivatives and attempt at chemoselective asymmetric Pummerer reaction.   Chemical & pharmaceutical bulletin (2002), 50(4), 558-562.

  • Nagao, Yoshimitsu; Miyamoto, Satoshi; Hayashi, Kazuhiko; Mihira, Ado; Sano, Shigeki.  Highly chemoselective Pummerer reactions of sulfinyldiacetic acid derivative.   Tetrahedron Letters (2002), 43(8), 1519-1522.

  • Hayashi, Kazuhiko; Hiki, Shinsuke; Kumagai, Toshio; Nagao, Yoshimitsu.  Synthesis of azetidine derivatives using 1-azabicyclo[1.1.0]butane.   Heterocycles (2002), 56(1-2), 433-442.

  • Sano, S.; Miwa, T.; Hayashi, K.; Nozaki, K.; Ozaki, Y.; Nagao, Y..  Chemoenzymatic total synthesis of (+)-conagenin, a low-molecular-weight immunomodulator.   Tetrahedron Letters (2001), 42(24), 4029-4031.

  • Hayashi, Kazuhiko; Kumagai, Toshio; Nagao, Yoshimitsu.  Improved synthesis of an energetic material, 1,3,3-trinitroazetidine exploiting 1-azabicyclo[1.1.0]butane.   Heterocycles (2000), 53(2), 447-452.

  • Hayashi, Kazuhiko; Sato, Chisato; Hiki, Shinsuke; Kumagai, Toshio; Tamai, Satoshi; Abe, Takao; Nagao, Yoshimitsu.  Novel efficient synthesis of 1-azabicyclo[1.1.0]butane and its application to the synthesis of 1-(1,3-thiazolin-2-yl)azetidine-3-thiol useful for the pendant moiety of an oral 1b-methylcarbapenem antibiotic L-084.   Tetrahedron Letters (1999), 40(19), 3761-3764. 

  • Kumagai, Toshio; Tamai, Satoshi; Abe, Takao; Matsunaga, Hiroshi; Hayashi, Kazuhiko; Kishi, Ikuo; Shiro, Motoo; Nagao, Yoshimitsu.  New Straightforward Synthesis and Characterization of a Unique 1b-Methylcarbapenem Antibiotic Biapenem Bearing a s-Symmetric Bicyclotriazoliumthio Group as the Pendant Moiety.   Journal of Organic Chemistry (1998), 63(23), 8145-8149.

  • Sano, Shigeki; Hayashi, Kazuhiko; Miwa, Toshio; Ishii, Takahiro; Fujii, Michiho; Mima, Hiromi; Nagao, Yoshimitsu.  New enantiodivergent procedure for the syntheses of chiral a-substituted serines from a-alkyl-a-aminomalonates utilizing enzymic hydrolysis.   Tetrahedron Letters (1998), 39(31), 5571-5574.

  • Hayashi, Kazuhiko; Kogiso, Hiromi; Sano, Shigeki; Nagao, Yoshimitsu.  Variable stereoselectivity in the imine aldol reactions employing MgBr2 and Et3N.   Synlett (1996), 1203-1205.

  • Konno, Shoetsu; Sagi, Mataichi; Takaharu, Etsuko; Fujimura, Satoshi; Hayashi, Kazuhiko; Yamanaka, Hiroshi.  Studies on as-triazine derivatives.  XII.  Synthesis of alkenyl-1,2,4-triazine derivatives.   Chemical & Pharmaceutical Bulletin (1988), 36(5), 1721-6.

  • Sakamoto, Takao; Kondo, Yoshinori; Miura, Norio; Hayashi, Kazuhiko; Yamanaka, Hiroshi.  Condensed heteroaromatic ring systems.  XI.  A facile synthesis of isoquinoline N-oxides.   Heterocycles (1986), 24(8), 2311-14.


特許　patent

  • Chambers, Richard Dickinson; Hayashi, Kazuhiko; Okazoe, Takashi.  Preparation of high-purity 2-monofluoro-3-oxoalkanoic acids by fluorination using them as solvents.   Jpn. Kokai Tokkyo Koho (2004), 10 pp. JP 2004292413 A2 20041021.

  • Taniguchi, Tomoko; Hayashi, Kazuhiko; Morizawa, Yoshitomi.  Process for preparation of 5-methyl-1-phenyl-2(1H)-pyridinone by phenylation of 5-methyl-2(1H)-pyridinone with bromobenzene.   PCT Int. Appl. (2003), 16 pp. WO 2003014087 A1 20030220. 

  • Hayashi, Kazuhiko; Oharu, Kazuya; Matsumura, Yasushi; Morisawa, Yoshitomi.  Preparation of fluorolactic acids by Grignard reaction.   Jpn. Kokai Tokkyo Koho (2003), 10 pp. JP 2003252831 A2 20030910.

  • Hayashi, Kazuhiko.  Preparation of 2,4,5-trifluoro-3-methyl-6-nitrobenzoic acid.  Jpn. Kokai Tokkyo Koho (2003), 10 pp. JP 2003335730 A2 20031128

  • Wang, Shuzhong; Hayashi, Kazuhiko; Kaga, Shinsuke; Oharu, Kazuya.  Process for producing fluorine compounds having geminal-difluoro structures.   PCT Int. Appl. (2002), 24 pp. WO 2002060853 A1 20020808

  • Hayashi, Kazuhiko; Onishi, Keiichi; Morisawa, Yoshitomi.  Isolation of alcohols.   Jpn. Kokai Tokkyo Koho (2002), 11 pp.  JP 2002167364 A2 20020611.

  • Hayashi, Kazuhiko; Onishi, Keiichi.  Preparation of alkoxyfluorobenzenes.   Jpn. Kokai Tokkyo Koho (2002), 4 pp. JP 2002255885 A2 20020911.

  • Taniguchi, Tomoko; Hayashi, Kazuhiko; Oharu, Kazuya.  Process for producing purified piperidine derivative by salt formation and dissolution in aqueous acid and basification for recrystallization.   PCT Int. Appl. (2002), 16 pp. WO 2002085858 A1 20021031.

  • Yoshiga, Shinsuke; Hayashi, Kazuhiko; Hiroharu, Kazuya.  Preparation of gem difluorides.   Jpn. Kokai Tokkyo Koho (2002), 7 pp. JP 2002338517 A2 20021127

  • Hayashi, Kazuhiko; Sato, Chisato; Tamai, Satoshi; Abe, Takao; Isoda, Takeshi; Mihira, Ado; Kumagai, Toshio. Preparation of thiazolinylazetidin-3-ylthiocarbapenemcarboxylate derivs.   U.S. Patent (1998), 31 pp., Cont.-in-part of U.S. 5,659,043. 

  • Hayashi, Kazuhiko; Sato, Chisato; Tamai, Satoshi; Abe, Takao; Isoda, Takeshi; Mihira, Ado; Kumagai, Toshio.  Preparation of thiazolinylazetidin-3-ylthiocarbapenemcarboxylate derivs.   U.S. Patent (1998),  31 pp., Cont.-in-part of U.S. 5,659,043.

  • Hayashi, Kazuhiko; Isoda, Taketoshi; Abe, Takao; Kumagai, Toshio.  Preparation of 2-(pyridinylthio)carbapenem analogs as antibacterials.   Jpn. Kokai Tokkyo Koho (1996), 17 pp. JP 08012676 A2 19960116 Heisei.  

  • Hayashi, Kazuhiko; Isoda, Taketoshi; Abe, Takao; Kumagai, Toshio.  Preparation of 2-[(4-halophenyl)thio]carbapenem analogs as antibacterials.   Jpn. Kokai Tokkyo Koho (1996), 18 pp.  JP 08012675 A2 19960116 Heisei.

  • Kaneda, Soichi; Hayashi, Kazuhiko; Kumagai, Toshio.  Preparation of crystalline 1-methyl-2-diphenylphosphoryloxycarbapenem compound.   Jpn. Kokai Tokkyo Koho (1992), 6 pp.  JP 04330085 A2 19921118 Heisei.

  • Kumagai, Toshio; Hayashi, Kazuhiko; Nagase, Junosuke.  4-Substituted-2-azetidinone derivatives, active amides as their intermediates, and their preparation.   Jpn. Kokai Tokkyo Koho (1990), 18 pp. JP 02292269 A2 19901203 Heisei.

金城学院大学薬学部　林一彦研究室

〒463-8521
名古屋市守山区大森二丁目１７２３番地

TEL 052-798-0180（代表）
FAX 052-798-0754